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In addition to different signal strength, the distinct conformation of c-MET triggered by different types of ligand may allow it to preferentially activate different downstream signaling pathways through engaging distinct sets of downstream effectors, which is reminiscent of the biased agonism paradigm established for other RTKs, such as EGFR 35

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In some embodiments, the concentration of the cyclodextrin used in the formulations or compositions and methods disclosed herein vary according to the physiochemical properties, pharmacokinetic properties, side effect or adverse events, formulation or composition considerations, or other factors associated with the therapeutic agent, or a salt or prodrug thereof

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Incorporation of Cu-Containing bioactive glass nanoparticles in Gelatin-Coated scaffolds enhances bioactivity and osteogenic activity

Acknowledgements The authors work was supported in part by grants from the National Natural Science Foundation of China (81870474), the National Institutes of Health (DK058831, DK087843) and the US Department of Veterans Affairs (BX000319)